Question

Which of the following observations would most strongly suggest the BoY might not be the TDF?

(a) Some XY individuals that develop into females have mutations in a different gene, SRY, but are normal at BoY
(b) BoY is not expressed in the adult male testes
(c) Expression of BoY in adult females does not masculinize them
(d) A few of the genes that are known to be expressed only in the testes have binding sites for BoY protein in their upstream regulatory sequences but most do not

Answer 1

The observation that would most strongly suggest that BoY might not be the TDF (Testis-determining Factor) is that a few of the genes expressed only in the testes have binding sites for BoY protein in their upstream regulatory sequences but most do not.

Step-by-step explanation:

The observation that would most strongly suggest that BoY might not be the TDF (Testis-determining Factor) is (d) A few of the genes that are known to be expressed only in the testes have binding sites for BoY protein in their upstream regulatory sequences but most do not. This observation indicates that BoY may not be directly involved in the development of male sex characteristics. The lack of binding sites for BoY protein in most genes expressed only in the testes suggests that other factors may be responsible for testis differentiation.