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Which of the following conditions is a risk factor for mural thrombi, cerebral vasculitis, TTP, PV, and SCA?

Option 1: Atrial fibrillation (AFib)
Option 2: Hypertension
Option 3: Diabetes mellitus
Option 4: Chronic obstructive pulmonary disease (COPD)

1 Answer

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Final answer:

Hypertension is the condition that increases the risk for mural thrombi, cerebral vasculitis, TTP, PV, and SCA, as it damages blood vessels and leads to atherosclerosis, which can result in thrombosis and other cardiovascular complications.

Step-by-step explanation:

The condition that is a risk factor for mural thrombi, cerebral vasculitis, TTP, PV, and SCA out of the options provided is Hypertension. Hypertension, or high blood pressure, is a major risk factor for various cardiovascular and thrombotic disorders due to its damaging effects on blood vessels, which can lead to atherosclerosis and increase the likelihood of thrombosis. This can cause complications like mural thrombi (clots in the wall of blood vessels) and other vascular conditions, manifested in diseases such as polycythemia vera (PV) and sickle cell anemia (SCA).

Thrombophilia, the tendency to develop thrombosis, may be influenced by acquired risk factors such as hypertension, diabetes, obesity, which are also associated with a higher risk of cardiovascular diseases. People with diabetes have a significantly higher chance of dying from cardiovascular disease, and high blood pressure is estimated to account for a significant percentage of cardiovascular disease deaths.

It is noteworthy that while each of the listed conditions (atrial fibrillation, diabetes mellitus, COPD) may be associated with cardiovascular risk in some way, hypertension stands out as directly contributing to the pathophysiology endemic to the disorders mentioned in the question.

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