Question

What is the term for the repair mechanism that recognizes gross distortions in the helical DNA structure?

A) Base excision repair (BER)
B) Nucleotide excision repair (NER)
C) Mismatch repair (MMR)
D) Homologous recombination (HR)

Answer 1

Nucleotide excision repair (NER) is the term for the repair mechanism that recognizes gross distortions in the helical DNA structure.B) Nucleotide excision repair (NER)

Step-by-step explanation:

The repair mechanism that recognizes gross distortions in the helical DNA structure is Nucleotide excision repair (NER). NER repairs damage affecting longer strands of 2-30 bases and recognizes bulky, helix-distorting changes such as thymine dimers as well as single-strand breaks. A specialized form of NER known as Transcription-Coupled Repair (TCR) deploys high-priority NER repair enzymes to actively transcribed genes.