Final answer:
Skin cancer is not directly associated with Metabolic Syndrome, which is characterized by abdominal obesity, high blood pressure, high fasting blood glucose, and dyslipidemia.
Step-by-step explanation:
The health issue that is NOT directly associated with Metabolic Syndrome is skin cancer. Metabolic Syndrome is a condition that includes a cluster of health issues, primarily abdominal obesity, high blood pressure, high fasting blood glucose, and dyslipidemia, particularly increased triglycerides and reduced HDL cholesterol levels. These factors are risk indicators for cardiovascular diseases and type 2 diabetes. Skin cancer, while a serious health condition, is not directly related to Metabolic Syndrome and its associated risk factors such as obesity, diet, and physical inactivity.