Final answer:
Hypopigmentation in dermatological lesions is primarily caused by inflammation, not sun exposure, genetic factors, or hormonal imbalance.
Step-by-step explanation:
The cause of hypopigmentation in dermatological response to damage lesions is C) Inflammation. When the skin is damaged, the inflammatory response can sometimes lead to a decrease in pigment production. Conditions such as albinism and vitiligo involve a lack of pigmentation, with albinism being a genetic condition where melanocytes fail to produce melanin, and vitiligo possibly stemming from an autoimmune reaction where melanocytes lose their pigment-producing capacity. Conversely, sun exposure, particularly UV-B radiation, is more likely to cause hyperpigmentation or an increase in skin pigmentation as a protective response against DNA mutations and potential skin cancer.