Question

Which second generation is active against ANAEROBES (B.fragilis)?

Answer 1

Cefoxitin, cefotetan and cefmetazole are more active against B.fragilis. Cefoxitin is the most effective cephalosporin against the B.fragilis group.

Answer 2

Second-generation cephalosporins, cefoxitin and cefotetan, are effective against Bacteroides fragilis due to their beta-lactamase stability and broad spectrum of antibacterial activity.

Step-by-step explanation:

Among the second-generation cephalosporins, cefoxitin and cefotetan have the capability to act against anaerobes like Bacteroides fragilis. These antibiotics are effective due to their enhanced beta-lactamase stability and thus maintain their activity in the presence of bacterial beta-lactamase enzymes that many anaerobic bacteria produce. Cefoxitin and cefotetan exhibit a broad spectrum of activity and are particularly useful in treating infections caused by these anaerobic bacteria.