Question

Loss of function in cak resembles what?

a) S phase arrest
b) G1 phase arrest
c) M phase arrest
d) G2 phase arrest

Answer 1

Loss of function in cak resembles G1 phase arrest, where the cell proceeds directly from G1 to S phase without proper evaluation of internal and external conditions, resulting in a shortened cell cycle and the production of daughter cells with inherited mutated p53 genes.

Step-by-step explanation:

The loss of function in cak resembles G1 phase arrest. Loss of p53 function severely compromises the G1 checkpoint, allowing the cell to proceed directly from G1 to S phase without proper evaluation of internal and external conditions. This results in a shortened cell cycle and the production of daughter cells with inherited mutated p53 genes. These daughter cells quickly accumulate mutations in oncogenes and non-functional tumor suppressor genes, leading to tumor growth.