Question

Bent vs upright conformation of integrins, which is active form and which is inactive form, which can and which cannot bind ligands in the ECM?

Answer 1

The active form of integrins is the bent conformation, which can bind ligands in the ECM. The inactive form is the upright conformation, which cannot bind ligands.

Step-by-step explanation:

The active form of integrins is the bent conformation, while the inactive form is the upright conformation. The bent conformation allows integrins to bind to ligands in the extracellular matrix (ECM), while the upright conformation cannot bind ligands. When a ligand binds to an integrin, it causes conformational changes that activate the intracellular domain of the integrin and initiate a signaling pathway.