Final answer:
The statement that systemically, TNF-α may be deadly is true. High systemic levels of TNF-α can trigger severe immune reactions that lead to septic shock and potentially result in multiple organ failure and death.
Step-by-step explanation:
Systemically, TNF-α (Tumor Necrosis Factor-alpha) may indeed be deadly, and this statement is true. TNF-α was first identified for its role in necrosis of tumors, but it is also a critical component of the body's immune defense against infections, such as those caused by gram-negative bacteria like Y. pestis. At low concentrations, TNF-α is vital for the immune response; however, when TNF-α circulates in high concentrations systemically, it can lead to a severe immune reaction, including vasodilation, increased vascular permeability, and edema, resulting in septicemia or septic shock. This condition can cause blood pressure to fall dangerously low, leading to multiple organ failure and possibly death due to inadequate oxygen and nutrients being delivered to cells and organs.