Question

A patient sustains significant burns to the skin and is experiencing fluid shift associated with edema in the fluid overload phase. The nurse would anticipate that this will interfere most with which phase of pharmacokinetics?

A. Absorption
B. Distribution
C. Metabolism
D. Excretion

Answer 1

The nurse would anticipate that the fluid shift associated with edema in the fluid overload phase will interfere most with the Distribution phase of pharmacokinetics.

Step-by-step explanation:

The nurse would anticipate that the fluid shift associated with edema in the fluid overload phase will interfere most with the Distribution phase of pharmacokinetics. Distribution refers to the process by which a drug moves from the bloodstream to various tissues and organs, allowing it to reach its target site of action. In the case of significant burns and fluid shift, edema can disrupt the normal distribution of drugs by affecting blood flow and altering the permeability of blood vessels, making it difficult for drugs to reach their intended sites.