Question

In addition to loss of heterozygosity, the second hit in sporadic breast cancers with breast cancer gene 1 (BRCA1) or breast cancer gene 2 (BRCA2) mutations is often which of the following?

A Methylation of the BRCA1 or BRCA2 promoter
B Acetylation of the BRCA2 or BRCA2 promoter
C Deletion of the tumor-associated transplantation antigen (TATA) box in BRCA1 or BRCA2
D Deletion of a BRCA1 or BRCA2 enhancer
E Nonsense mutation in BRCA2 or BRCA2

Answer 1

The second hit in sporadic breast cancers with BRCA1 or BRCA2 mutations is often methylation of the BRCA1 or BRCA2 promoter.

Step-by-step explanation:

In addition to loss of heterozygosity, the second hit in sporadic breast cancers with breast cancer gene 1 (BRCA1) or breast cancer gene 2 (BRCA2) mutations is often Methylation of the BRCA1 or BRCA2 promoter.