Question

In addition to mutations in α globin, α thalassemia can result from mutations in which of the following genes?

A β globin
B γ globin
C (XIST) C and D are gene names and don't need to be spelled out
D (ATRX)
E A or B

Answer 1

In addition to α globin mutations, α thalassemia can also result from mutations in the ATRX gene. Mutations in other globin genes lead to different types of hemoglobinopathies and are not associated with α thalassemia.

Step-by-step explanation:

In addition to mutations in α globin, α thalassemia can result from mutations in the gene (ATRX). While β globin mutations lead to β-thalassemia, α thalassemia is specifically associated with issues in α chain synthesis. However, mutations in α globin are not the sole cause of α thalassemia, as the ATRX gene can also be responsible for this condition. The ATRX gene plays a vital role in hemoglobin production, and its mutations can hinder the proper formation of α globin chains, thereby contributing to the development of α thalassemia. Mutations in other globin genes like β or γ do not result in α thalassemia but other types of hemoglobinopathies, such as β-thalassemia or sickle cell anemia.