Final answer:
Long-term depression (LTD) is the weakening of a synaptic connection due to the removal of AMPA receptors from the postsynaptic membrane. LTD allows for the pruning of unused synapses and strengthening of synapses that have undergone long-term potentiation (LTP).
Step-by-step explanation:
Long-term depression (LTD) is the long-term weakening of a synaptic connection. It involves the removal of AMPA receptors from the postsynaptic membrane when calcium enters through NMDA receptors. Long-term depression (LTD) is the weakening of a synaptic connection due to the removal of AMPA receptors from the postsynaptic membrane.
LTD allows for the pruning of unused synapses and strengthening of synapses that have undergone long-term potentiation (LTP). This makes the neuron less responsive to glutamate. LTD is important for learning and memory as it allows for the pruning of unused synapses and strengthens the synapses that have undergone long-term potentiation (LTP).