Final answer:
Hydromorphone-dihydromorphinone does not require TPP to be synthesized.
Step-by-step explanation:
Hydromorphone-dihydromorphinone does not require TPP (Triphenylphosphine) to be synthesized.
TPP is a phosphine reagent commonly used in chemical reactions, but it is not mentioned in any of the sources provided in the question in relation to the synthesis of Hydromorphone-dihydromorphinone.
The references mainly discuss the opioid systems, neurochemical functions, and the structure-activity relationships of opioids.