Question

What is the structural basis for the effect of 2,3-Bisphosphoglycerate (BPG) on oxygen binding by Hemoglobin?

a) Induction of T state
b) Induction of R state
c) No structural change
d) Disruption of heme binding

Answer 1

2,3-Bisphosphoglycerate (BPG) affects oxygen binding by Hemoglobin by inducing the T state and causing structural changes.

Step-by-step explanation:

2,3-Bisphosphoglycerate (BPG) affects oxygen binding by Hemoglobin by inducing the T state, not by inducing the R state, causing structural changes.

BPG disrupts the binding of oxygen to heme, resulting in the release of additional oxygen molecules.

This change in structure allows for greater oxygen dissociation from hemoglobin, despite the partial pressure of oxygen.