Final answer:
The rate of filtration across the glomerulus is determined by the pressure difference between the glomerulus and Bowman's capsule, the colloid osmotic pressure in the glomerulus, and the permeability of the glomerular membrane.
Step-by-step explanation:
The rate of filtration across the glomerulus is determined by several factors. One of the main factors is the difference in pressure between the glomerulus and Bowman's capsule. The glomerular hydrostatic pressure (GHP) is the pressure exerted by the blood in the glomerulus, while the luminal hydrostatic pressure (LHP) is the pressure exerted by the fluid in the Bowman's capsule. If GHP is greater than LHP, filtration occurs.
Another factor is the colloid osmotic pressure (COP) in the glomerulus. COP is the pressure exerted by the proteins in the blood. The higher the COP, the less filtration occurs.
Additionally, the permeability of the glomerular membrane also affects the rate of filtration. This membrane has small openings called fenestrations, which allow smaller solutes like water and ions to pass through while preventing larger molecules like proteins from passing through.