Final answer:
The best practice in setting up a Web interface for public users of an Information and Referral (I&R) resource database is to provide clear and simple navigation to ensure accessibility and convenience for all users.
Step-by-step explanation:
In setting up a Web interface for public users of an Information and Referral (I&R) resource database, the best practice would be to provide clear and simple navigation. This ensures that users of all technical backgrounds can easily find the information they need without unnecessary barriers. Restricting access to registered users only may dissuade some potential users, while the use of complex technical jargon can be confusing and off-putting. Similarly, limiting the number of available resources does not serve the purpose of an I&R database, which is to provide comprehensive information. Therefore, a well-designed Web interface should strive for inclusivity and clarity.