Question

A 46-year-old man is a known asthmatic and has been on a carefully titrated dose of theophylline for 14 years without any complications. Recently, he sought medical attention for malaise, persistent cough, and weight loss. He was diagnosed with tuberculosis. During visits to the clinic for diagnosis and initiation of treatment for tuberculosis, he was also discovered to be hypertensive and to have acid peptic disease. He was put on medication for all 3 conditions. After 2 weeks of therapy, the patient had a seizure and was rushed to the emergency department. Reports showed a tearing of the bridging veins between the dural sinuses and an increase in the plasma theophylline concentration in the large cerebral veins. What drug is most likely to have caused the theophylline toxicity?

1. Atenolol
2. Cimetidine
3 Hydrochlorothiazide
4 Prazosin
5 Rifampin

Answer 1

The drug most likely to have caused the theophylline toxicity is Cimetidine.

Step-by-step explanation:

The drug most likely to have caused the theophylline toxicity in this case is Cimetidine. Cimetidine is a medication used to treat acid peptic disease, and it is known to inhibit the enzyme responsible for the metabolism of theophylline in the liver. This inhibition can result in an increased plasma concentration of theophylline, leading to toxicity.