Question

The major role of activated Factor XIII in the coagulation cascade is:

Option 1: Cross-linking fibrin to stabilize the clot.
Option 2: Converting fibrinogen to fibrin.
Option 3: Activating platelets.
Option 4: Inhibiting the release of tissue plasminogen activator.

Answer 1

Activated Factor XIII plays a major role in the coagulation cascade by cross-linking fibrin to stabilize the clot.

Step-by-step explanation:

The major role of activated Factor XIII in the coagulation cascade is cross-linking fibrin to stabilize the clot. Once thrombin converts soluble fibrinogen to insoluble fibrin protein strands, Factor XIII helps strengthen and stabilize the fibrin clot by forming covalent bonds between fibrin molecules.