Final answer:
General Stand Watie, a Cherokee leader, was the last Confederate general to surrender in June 1865 following the broader collapse of the Confederate resistance.
Step-by-step explanation:
The Cherokee leader who was the last Confederate general to surrender at the end of the Civil War was General Stand Watie. Watie, who was a Cherokee, led a Confederate army comprised of various Native American tribes and surrendered in June 1865. This surrender came after the rest of the Confederate resistance had largely dissipated following key events such as Lee's surrender to Grant at Appomattox Courthouse in April 1865, and the capture of Jefferson Davis, the President of the Confederacy, in May 1865.