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Analyze a human karyotype to determine gender and whether non-disjunction has occurred

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A karyotype allows geneticists to identify an individual's gender and chromosomal abnormalities, such as non-disjunction, by analyzing the number and structure of chromosomes. Down Syndrome and Turner Syndrome are examples of conditions resulting from non-disjunction, whereas translocations can lead to certain cancers.

Step-by-step explanation:

By analyzing a human karyotype, geneticists can determine an individual's gender and whether non-disjunction has occurred. A typical female karyotype displays two X chromosomes (XX), while a male will have one X and one Y chromosome (XY). Non-disjunction is an error during meiosis where homologous chromosomes or sister chromatids fail to separate properly, leading to gametes with an abnormal number of chromosomes.

The presence of an extra chromosome, as seen in Down Syndrome (Trisomy 21), or a missing chromosome, as in Turner Syndrome (45,X), indicates that non-disjunction has occurred. Conditions like Jacobsen Syndrome, identified by a deletion in chromosome 11, and various cancers associated with translocations, demonstrate other types of chromosomal abnormalities that can be detected through a karyogram.

Geneticists use fluorescent stains and chromosome painting techniques to highlight and differentiate chromosomes, facilitating the detection and diagnosis of these genetic abnormalities.

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