Final answer:
Genetic mutations disrupting the slit diaphragm can result in health problems such as cystic fibrosis.
Step-by-step explanation:
Genetic mutations that disrupt the slit diaphragm can lead to various health problems. For example, in the case of cystic fibrosis, a genetic mutation in the CFTR gene results in the production of a faulty protein that affects the movement of sodium chloride in and out of cells. As a result, the mucus becomes abnormally thick and sticky, leading to respiratory and sinus infections, as well as malabsorption. The disruption of the slit diaphragm in genetic mutations can cause a range of negative health impacts depending on the specific gene affected and the resulting protein defect.