Question

In addition to acting as a comparison to the post-partition salicylic acid solution, the pre-partition salicylic acid solution (no mixing with chloroform) serves a 2nd propose to:

calculate the proportionality coefficient of Fick's First Law
calculate the pKa of salicylic acid
calculate the diffusion coefficient of the drug across a GI membrane
act as a standard for linear regression analysis

Answer 1

To find the pH of a saturated solution of salicylic acid and aspirin, you can use the ionization constants of the functional groups and the pH equation.

Step-by-step explanation:

The pH of a saturated solution of salicylic acid can be calculated by considering the ionization of both functional groups (-CO₂H and -OH) in water. The ionization constants, Ka, for these groups are given as 1.0 × 10-3 and 4.2 x 10-13 respectively. To find the pH, you can use the equation pH = -log[H+], where [H+] is the concentration of the hydronium ion.

For the aspirin solution, you can use the same approach but with the ionization constant for the -CO₂H group of aspirin, which is given as 3.0 x 10-4. Determine the concentration of the hydronium ion and use the pH equation to find the pH