Question

St. John's wort, an herbal supplement, impacts the metabolism of drugs because it significantly induces the activity of:

A. proton-pump inhibitors
B. CYP 2B6
C. MAOIS
D. CYP 3A4
E. H2 blockers

Answer 1

St. John's wort induces the activity of CYP 3A4, which is involved in the metabolism of many drugs, possibly affecting their effectiveness.

Step-by-step explanation:

St. John's wort, an herbal supplement, impacts the metabolism of drugs because it significantly induces the activity of CYP 3A4. The cytochrome P450 family of enzymes, especially CYP 3A4, plays a crucial role in the metabolism of many drugs. Induction of CYP 3A4 by St. John's wort can accelerate the metabolism of drugs that are substrates of this enzyme, potentially reducing their effectiveness or requiring dosage adjustments.