Final answer:
It is true that mediator proteins can bind both chromatin remodelers and transcription activator proteins to enhance the transcription of a gene.
Step-by-step explanation:
True, mediator proteins can indeed bind both chromatin remodelers and transcription activator proteins to enhance transcription. Mediator proteins function as a bridge to facilitate the interaction between DNA and various factors needed for transcription.
These mediators can bind to transcription activators, which are attached to distal control elements of enhancers and subsequently bring about conformational changes that facilitate the recruitment and assembly of the transcription initiation complex at the promoter. This, in turn, enhances the efficiency at which RNA polymerase II can initiate the transcription of a gene.