Question

The two signal sequences required for transport of nucleus-encoded proteins into the mitochondrial inner membrane via the TIM23 complex are cleaved off the protein in different mitochondrial compartments. True or False?

Answer 1

True. Two signal sequences are required for transport of nucleus-encoded proteins into the mitochondrial inner membrane via the TIM23 complex.

Step-by-step explanation:

True. The transport of nucleus-encoded proteins into the mitochondrial inner membrane via the TIM23 complex requires two signal sequences. The first signal sequence is a recognized N-terminal signal peptide on the outer mitochondrial membrane that binds to a receptor protein. The second signal sequence is a hydrophobic stop-transfer sequence within the polypeptide chain, which traps the protein in the mitochondrial inner membrane.