Final answer:
The initiator protein is not the only sequence-specific DNA binding protein involved in the initiation of replication, as helicase, SSBs, topoisomerases, among others, also play key roles. the correct option is false.
Step-by-step explanation:
The statement that the initiator protein is the only sequence-specific DNA binding protein involved in the initiation of replication is False. During the initiation of DNA replication, several proteins interact with the origin of replication. Not only do initiator proteins bind to the specific sequences at the replication origins, but other proteins such as helicase, single-strand binding proteins (SSBs), and topoisomerase play important roles in unwinding the DNA and stabilizing the single-stranded DNA to facilitate replication. In eukaryotic cells, additional factors such as regulatory proteins and histone-modifying enzymes also partake in the processes that precede the actual replication to ensure that the replication machinery has access to the DNA.