Final answer:
The removal of the mismatched base allows the primer:template junction to re-form and rebind the polymerase active site, enabling DNA synthesis to continue.
Step-by-step explanation:
The removal of the mismatched base allows the primer:template junction to re-form and rebind the polymerase active site, enabling DNA synthesis to continue. This statement is true.
During DNA replication, DNA polymerase proofreads the newly added base before adding the next one. If an incorrect base is added, the polymerase removes the wrong nucleotide and replaces it with the correct one. This allows the primer:template junction to re-form and rebind the polymerase active site, allowing DNA synthesis to continue.
For example, if an incorrect base is added to the newly synthesized strand, the exonuclease action of DNA polymerase removes the mismatched base, enabling the correct base to be added and the synthesis to continue.