Final answer:
Cachexia (weight loss, muscle wasting) can be an early sign of malignancy of local structures.
Step-by-step explanation:
The early sign of malignancy of local structures can depend on the specific type of cancer. However, one common early sign is an unusual lump or swelling in the affected area. Other early signs can include hemorrhage, pain, ulceration, enlarged lymph nodes, and specific paraneoplastic phenomena.
Out of the options provided, A. Cachexia (weight loss, muscle wasting) can be an early sign of malignancy of local structures. Cachexia is a body wasting syndrome commonly associated with cancer and can indicate the presence of an underlying malignancy.