Question

What are the three key factors mentioned in relation to Parkinson's disease?

a) Serotonin imbalance, gamma-aminobutyric acid (GABA) dysfunction, and amyloid plaque formation
b) Dopamine denervation, alpha-synuclein, beta-amyloid deposition
c) Cortisol overproduction, insulin resistance, and acetylcholine deficiency
d) White blood cell count, platelet aggregation, and hemoglobin levels

Answer 1

The three key factors in Parkinson's disease are loss of dopamine neurons, presence of Lewy bodies, and glutamate excitotoxicity.

Step-by-step explanation:

The three key factors mentioned in relation to Parkinson's disease are loss of dopamine neurons, presence of protein aggregates called Lewy bodies, and glutamate excitotoxicity.

Loss of dopamine neurons in the substantia nigra leads to a reduction in dopaminergic innervation, resulting in motor symptoms such as tremors, slowed movement, and rigidity.

The presence of Lewy bodies, which are abnormal protein clumps, is observed in dopaminergic neurons and often correlates with the severity of the disease.

Glutamate excitotoxicity, characterized by an increase in glutamatergic activity, plays a role in the motor symptoms and neurodegenerative processes in Parkinson's disease.