Final answer:
In a migrating cell, the actin-myosin interactions that generate the contractile force necessary to pull the bulk of the cell forward are mostly located in the lamella, closer to the cell body.
Step-by-step explanation:
The actin-myosin interactions that generate the contractile force necessary to pull the bulk of a migrating cell forward are mostly located in the lamella, which is closer to the cell body. In stationary or slowly migrating cells, the sites of adhesion are typically located between the polymerization-dominated lamellipodium and the myosin-dominated contractile structures in the lamella, resulting in inward-directed forces on the substrate. This leads to a traction force pattern that resembles a pair of opposing forces on the substrate.