Final answer:
Alchemists became more cautious as they traveled due to encountering perils and challenges such as regional disputes, adverse weather conditions, illness, and banditry.
Step-by-step explanation:
As alchemists traveled, they became more cautious due to encountering various perils and challenges. These included regional disputes, adverse weather conditions, illness, and banditry. Crossing borders without established networks or support systems made the journey exceptionally risky. Additionally, travel in the fourteenth century was expensive, and most people could only afford to walk as a means of transportation. All these factors contributed to the alchemists' increasing caution.
Travel in the fourteenth century was expensive and walking was the common means of transportation.