Final answer:
The rough endoplasmic reticulum and ribosomes work directly in conjunction with each other in the cell.
Step-by-step explanation:
The organelles that work directly in conjunction with each other are the Rough endoplasmic reticulum and the ribosomes. The rough endoplasmic reticulum (RER) is responsible for protein synthesis and modification, while ribosomes are the site where proteins are synthesized.