Final answer:
The deduction of automobile title and registration fees as itemized deductions is generally false, with some exceptions related to business use.
Step-by-step explanation:
The answer to whether automobile title and registration fees are deductible as itemized deductions on a federal income tax return is generally false. According to the Tax Cuts and Jobs Act of 2017, individuals are prohibited from deducting personal expenses such as costs for registering a personal automobile.
There are some exceptions to this rule, for example, if the automobile is used for business purposes, in which case the expenses would have to be related to the business use of the vehicle and properly documented.