Final answer:
No, spouses filing separate returns do not have to itemize their deductions if the itemized deductions are less than the standard deduction for one of the spouses.
Step-by-step explanation:
No, if spouses are filing separate returns, both spouses do not have to itemize their deductions. They have the option to choose between itemizing their deductions or taking the standard deduction. It is not required for both spouses to itemize their deductions if the itemized deductions are less than the standard deduction for one of the spouses.