Question

True/False : Acetylation of the N terminal tail of histone H3 is important for transcriptional repression.

Answer 1

Acetylation of histone H3 is typically associated with transcriptional activation, not repression, as it leads to loosened chromatin structure and allows access for transcription factors.

Step-by-step explanation:

The statement that acetylation of the N terminal tail of histone H3 is important for transcriptional repression is False. Instead, histone acetylation, including that of the N terminal tail of histone H3, is generally associated with transcriptional activation rather than repression. This chemical modification results in a loosened structure of chromatin, allowing transcription factors easier access to DNA, thereby promoting gene expression. In contrast, deacetylation of histones usually leads to chromatin condensation and transcriptional repression.