Final answer:
If DNA is too negatively supercoiled, it can disrupt DNA functioning and cause physical damage.
Step-by-step explanation:
DNA supercoiling refers to the process by which DNA is twisted to fit inside a cell. If DNA is too negatively supercoiled, it may lead to various problems. For example, it can disrupt the normal functioning of the DNA, such as impairing replication and transcription processes. It can also cause physical damage to the DNA, leading to DNA breaks and fragmentation.