asked 174k views
4 votes
In normal vs. Alzheimer's processing, how many amino acid (aa) APP fragments are typically found?

a) 10-20 aa
b) 30-40 aa
c) 50-60 aa
d) 70-80 aa

asked
User AdRock
by
7.5k points

1 Answer

6 votes

Final answer:

Enzymatic cleavage of APP typically produces extracellular Ab peptides of 39-43 amino acids in length, which are digested under normal conditions but accumulate and form plaques in Alzheimer's disease.

Step-by-step explanation:

In the comparison of normal vs. Alzheimer's processing, enzymatic cleavage of the amyloid precursor protein (APP) typically produces extracellular amyloid beta (Ab) peptides consisting of 39-43 amino acids. Normally, these Ab peptides are further digested to prevent accumulation. However, in Alzheimer's disease, these peptides can accumulate and form the characteristic extracellular amyloid plaques.

answered
User Pallavi
by
8.4k points
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