Final answer:
The Native Americans under Pontiac's leadership responded to western expansion by Britain and its colonists by forming a confederacy known as Pontiac's Rebellion to drive the British out of their lands. The rebellion led to attacks on British forts and settlements, resulting in casualties on both sides. The Proclamation of 1763 was issued in response to the war and restricted British colonists from settling west of the Appalachian Mountains.
Step-by-step explanation:
The Native Americans under Pontiac's leadership responded to western expansion by Britain and its colonists by forming a confederacy known as Pontiac's Rebellion. By incorporating the teachings of the prophet Neolin, Pontiac called for tribes to unite against the British and drive them out of their lands. The rebellion led to attacks on British forts and settlements, causing significant casualties on both sides. In response to the war, Britain enacted the Proclamation of 1763, which restricted British colonists from settling west of the Appalachian Mountains.