Final answer:
Genes in DNA can be oriented in different directions, which is true. Gene orientation variability is a critical aspect of genetic regulation, reflecting the complex nature of how genetic information is controlled and used within cells.
Step-by-step explanation:
The statement 'Genes can be located on DNA in either orientation' is true. Genes within DNA can indeed be oriented in different directions. This is because genes are stretches of DNA that contain instructions for making proteins, and the machinery that reads these instructions can process them in either direction along the DNA strand.
Each gene has its own promoter region, which signals the start point for transcription (the process of creating RNA from DNA), and this can be located on either the 'sense' or the 'antisense' strand. The versatility in gene orientation is an important aspect of the complexity and regulation of genetic information.