Question

Is GTPase activity dormant or active inside Ras-GTP? Who is responsible?

Answer 1

In certain cancers, the GTPase activity of the RAS G-protein is inhibited, leading to continuous activation of downstream cellular events.

Step-by-step explanation:

In certain cancers, the GTPase activity of the RAS G-protein is inhibited, meaning that the RAS protein cannot hydrolyze GTP into GDP. The GTPase activity of RAS is responsible for switching off the RAS signaling pathway by converting GTP to GDP. Therefore, when the GTPase activity is inhibited, the RAS protein remains active for longer periods, leading to continuous activation of downstream cellular events.