Final answer:
Local mediators, also known as paracrines, are chemicals that induce a response in neighboring cells and are involved in local intercellular communication.
Step-by-step explanation:
Local mediators, also known as paracrines, are chemicals that induce a response in neighboring cells and are involved in local intercellular communication. They act by binding to specific receptors on nearby cells and triggering a response. Examples of local mediators include histamine, cytokines, and growth factors.