Final answer:
Eukaryotic chromosomes have multiple origins of replication, not just one, enabling efficient replication of their long DNA strands.
Step-by-step explanation:
The statement Eukaryotic chromosomes contain a single replication origin is false. Eukaryotes, unlike prokaryotes, have linear chromosomes with multiple origins of replication to ensure that their longer DNA strands can be replicated in a reasonable amount of time. In contrast to prokaryotic replication that uses a single origin, eukaryotic DNA replication requires multiple replication forks. For example, human chromosomes can have up to 100,000 origins of replication, and the process involves many proteins and enzymes such as helicase, topoisomerase, and DNA polymerase for efficient completion.