Final answer:
Interleukin-10 (IL-10) is the cytokine that inhibits cytokine production from macrophages to down-regulate the immune response.
Step-by-step explanation:
The cytokine that inhibits cytokine production from macrophages to down-regulate the immune response is interleukin-10 (IL-10). IL-10 is one of the main inhibitors of activated immune cells, controlling innate immune reactions and cell-mediated immunity.
It regulates the immune response by suppressing the pro-inflammatory cytokines produced by macrophages.