Question

The "high" produced by ________ can be blocked by ________?

1) cocaine - dopamine autoreceptor agonists
2) alcohol - CB1 receptor agonists
3) marijuana - CB1 receptor antagonists
4) alcohol - GABAA receptor agonists
5) marijuana - GABAA receptor agonists

Answer 1

Cocaine acts as a stimulant by preventing nerve cells from taking up dopamine, resulting in high levels of dopamine and the production of a "high" feeling. However, this dopamine depletion leaves the user in a pleasureless state.

Correct option is 1.

Step-by-step explanation:

Cocaine acts as a stimulant by preventing nerve cells from taking up dopamine, another neurotransmitter, from the synapse. High levels of dopamine are therefore available to stimulate the pleasure centers of the brain. The enhancement of dopamine action is thought to be responsible for cocaine's "high" and its addictive properties. After the binge, dopamine is depleted in less than an hour. This leaves the user in a pleasureless state and (often) craving more cocaine.