Question

Kell antigens are glycoproteins that fold on themselves and attach at various places via disulfide bonds. This makes them susceptible to what reagent?

1) DTT
2) Chloroquine diphosphate
3) LISS
4) PEG

Answer 1

Kell antigens, which are glycoproteins, are susceptible to Dithiothreitol (DTT), a reagent that breaks disulfide bonds, denaturing the protein structure.

Step-by-step explanation:

Kell antigens are glycoproteins that are susceptible to reagents that break down disulfide bonds because of the way they are structured; they fold on themselves and attach at various places via these bonds. The reagent that is capable of breaking these bonds is Dithiothreitol (DTT), which is an appropriate answer to the student's question. DTT can reduce disulfide bonds in proteins to free sulfhydryl groups, thus denaturing the folded protein structure.