Question

Misfolding of polypeptides is a serious problem in cells. Which of the following diseases is (are) associated with an accumulation of misfolded polypeptides?

1) Alzheimer's only
2) Parkinson's only
3) Diabetes mellitus only
4) Alzheimer's and Parkinson's
5) Alzheimer's, Parkinson's, and diabetes mellitus

Answer 1

Misfolding of polypeptides can lead to the accumulation of misfolded proteins, which is associated with diseases such as Alzheimer's and Parkinson's. Type 2 diabetes can involve misfolding of proteins in other organ systems.

Step-by-step explanation:

Misfolding of polypeptides can lead to the accumulation of misfolded proteins, which is associated with certain diseases. In the case of Alzheimer's disease, there is accumulation of beta-amyloid plaques in the cerebral cortex. Parkinson's disease is linked to an increase in a protein called alpha-synuclein that is toxic to cells in the midbrain. Type 2 diabetes, while not typically associated with misfolded polypeptides, can involve misfolding of proteins in other organ systems.