Question

Functions of SH2 and PTB domains in signaling proteins. Where/when do you expect to find the residues that the above two domains would bind to?

Answer 1

The SH2 and PTB domains in signaling proteins bind to phosphotyrosine residues on proteins. The SH2 domain has specific sequence requirements, while the PTB domain has looser sequence requirements.

Step-by-step explanation:

The SH2 (Src Homology 2) and PTB (Phosphotyrosine Binding) domains are common in signaling proteins and play important roles in cell signaling pathways. These domains bind to specific residues on proteins that are phosphorylated, specifically phosphotyrosine residues. The SH2 domain binds to phosphotyrosine residues within a specific context, which is typically a specific amino acid sequence surrounding the phosphotyrosine residue. The PTB domain also binds to phosphotyrosine residues, but it does not have as strict sequence requirements as the SH2 domain.