Question

In contrast to peripheral tolerance, central tolerance _____________.

a) signals continuation of light-chain gene rearrangment
b) causes death of self-reactive B cells by apoptosis
c) induces a stage of anergy in self-reactive B cells
d) occurs in the circulation

Answer 1

Final Answer:

In contrast to peripheral tolerance, central tolerance b) causes death of self-reactive B cells by apoptosis.

Step-by-step explanation:

Central tolerance refers to the mechanisms by which self-reactive lymphocytes are eliminated or inactivated during their development in the central lymphoid organs (such as the thymus for T cells and the bone marrow for B cells).

b) Causes death of self-reactive B cells by apoptosis: Central tolerance involves the deletion (apoptosis) of self-reactive B cells to prevent the development of autoimmunity. This ensures that B cells that recognize self-antigens too strongly are eliminated.