Question

Which of the following are net products of the overall reaction catalyzed by the pyruvate dehydrogenase complex (including all steps)?

a) Acetyl-CoA
b) CO_2
c) NADH
d) All of the above

Answer 1

The net products of the overall reaction catalyzed by the pyruvate dehydrogenase complex are Acetyl-CoA, CO2, and NADH.

Step-by-step explanation:

The net products of the overall reaction catalyzed by the pyruvate dehydrogenase complex are Acetyl-CoA, CO2, and NADH. The pyruvate dehydrogenase complex is responsible for converting pyruvate, the end product of glycolysis, into Acetyl-CoA, which then enters the Krebs cycle.

In the first step, pyruvate dehydrogenase removes a carboxyl group from pyruvate, producing carbon dioxide. In the second step, dihydrolipoyl transacetylase transfers an enzyme-bound acetyl group to CoA, forming Acetyl-CoA. And finally, in the third step, an enzyme-bound hydroxyethyl group is oxidized to an acetyl group, producing NADH. Therefore, the correct answer is d) All of the above.